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KMID : 0370220120560050309
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Yakhak Hoeji
2012 Volume.56 No. 5 p.309 ~ p.313
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Antihypertensive and ACE Inhibitory Effects of Novel Isoflavone-free Black Soy Peptide Mixture
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Ahn Chang-Won
Shin Dong-Seok
Park Soo-Hyun
Hong Soon-Sun
Kang Ju-Hee
Park Chang-Shin
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Abstract
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Antiobesity, hypotriglyceridemic and antihypertensive activities of isoflavone-free peptide mixture (black soybean peptide, BSP) were reported in our previous experiments. In the present study, angiotensin converting enzyme inhibitory (ACEi) activity was decreased in the aorta tissues of spontaneously hypertensive rats (SHRs) treated with BSP (1% in drink water) for 4 weeks, but not in serum. BSP administration significantly decreased ACE activity by 17.5% (from 33.2± 4.5 to 27.4±
1.96 mUnit/mg, p=0.0013) in aorta tissue hydrolysate. BSP treatment also decreased significantly mean blood pressure (BP) from 213.0±16.96 to 184.0± 6.53 mmHg, p<0.0001) as expected. These results indicate that BSP has antihypertensive activity as well as ACEi activity.
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KEYWORD
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isoflavone-free peptide mixture, ACE, SHR, antihypertension
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